The regulation of hTERT expression occurs through multiple avenues including CpG promoter methylation,50 alternative splicing51 and so on, and transcriptional regulation is the limiting step.52 A number of factors have been identified to regulate the activity of the hTERT promoter directly or indirectly.53, 54, 55 To test if KMT2A anchored at the hTERT promoter to regulate its expression, ChIP assay was performed in melanoma cells. The gene discussed is KMT2A; the disease is melanoma.