Recurrent and mutually exclusive C>T or CC>TT transition mutations were identified in the promoter region of the reverse transcriptase catalytic subunit of the telomerase gene (TERT) in melanoma, suggesting that they enhanced the expression of TERT gene and played important roles in the melanoma pathogenesis.42 We also determined whether KMT2A bind to the segment of hTERT promoter associated with mutations. This evidence concerns the gene KMT2A and melanoma.