Our further analysis showed that KMT2A knockdown suppressed the expression of MMP2, MMP9 and promoted the cleavage of Caspase3/Caspase7/Caspase9 and PARP in melanoma cells, and repressed the expression of hTERT and the Nanog/oct-4/sox-2 stem cell markers. This evidence concerns the gene PLXNA2 and melanoma.