KMT2A and acute leukemia: KMT2A is a transcriptional co-activator with H3K4 methyltransferase activity.16 Its genetic rearrangements often result in ontogenetic fusion proteins causing acute leukemia in pediatric and adult patients.65, 66, 67 Here, we discovered that KMT2A regulated the expression of hTERT by binding to its promoter.