TERT and cancer: The highly recurrent mutations in the promoter of TERT are found in over 50 cancer types, including papillary thyroid carcinoma,36, 37 hepatocellular carcinoma,38 epithelioid glioblastoma,39 bladder cancer,40 malignant pleural mesothelioma,41 melanoma,42, 43, 44, 45 are the most common mutation in many cancers.