The most recurrent melanoma nucleotide substitution has been shown to include BRAF (chr7, 140,453,136A>T V600E), NRAS (chr1, 115, 256, 529T>C Q61R) and TERT core promoter mutations (C228T and C250T),44 but the precise mechanism behind the TERT activation in cancers remains largely unknown and need to be studied in the future. The gene discussed is TERT; the disease is cancer.