To discover and identify potential molecules and signaling pathways involved in the growth of melanoma, we screened a siRNA library targeting >6000 human genes in A375 melanoma cells and found that KMT2A knockdown by siRNA significantly suppressed the cell viability by 76.0% (Figure 1a), indicating that KMT2A, a transcriptional co-activator in cancer,15, 46, 47 could be a melanoma target. Here, KMT2A is linked to melanoma.