The protein kinase C (PKC) family consists of 12 structurally related members that function as serine/threonine kinases.6 PKC has essential roles in various fundamental cellular processes, including survival, proliferation, differentiation, and apoptosis.7 PKCζ is one member of the atypical protein kinase C (aPKC) subfamily,8 which is expressed in intestinal stem cells and colon cancer cells.9, 10, 11 PKCζ knockdown or dominant-negative PKCζ expression increases cell apoptosis,10, 11, 12 suggesting that PKCζ is an anti-apoptotic protein. This evidence concerns the gene PRRT2 and malignant colon neoplasm.