FOXQ1 and neoplasm: On the other hand, the degradation of FOXQ1 protein during cell senescence is considerable and the invalidation of this process might be the reason why high level of FOXQ1 protein is found in several kinds of tumor tissues and can thus promote cancer cell proliferation and metastasis.23, 24, 25, 26, 27, 28, 29 The mechanism through which FOXQ1 is degraded in cell senescence remain to be identified in the future study.