Noteworthy, aberrant Shh pathway activation is associated with various disorders, including medulloblastoma, the most common brain tumor in childhood affecting cerebellum.16, 44, 45, 46 The in silico analysis reported in Differential Atlas database shows that Maml1 expression increases in Shh-dependent medulloblastoma, when compared with healthy cerebellar tissue or other medulloblastoma subtypes (Supplementary Figure S1b). The gene discussed is SHH; the disease is brain neoplasm.