Thus, Mcc950 has an anti-inflammatory role in the pathogenesis of impaired glucose-mediated retinopathy, and these data agree with previous reports that Mcc950 can inhibit NLRP3 inflammasome activation in dermal and pulmonary inflammation,31 crystal-induced kidney fibrosis,33 valosin-containing protein-associated diseases,32 cryopyrin-associated periodic syndromes,20, 39, 40 hypertension,41 and myocardial infarction.42 Here, NLRP3 is linked to myocardial infarction.