Activation of the NLRP3 inflammasome is thought to be key for the progression of pro-inflammatory effects of retinopathy including age-related macular degeneration18 and DR.27 Using immunofluorescence and western blot we confirmed NLRP3 inflammasome activation in human REC of proliferative membranes, a crucial characteristic of PDR.28, 29, 30 The anti-NLRP3 inflammasome effect of Mcc950 for macrophages, microglia, myoblasts and dendritic cells is well described,31, 32, 33, 34 but its effect on inflammation of HRECs is unexplored. The gene discussed is NLRP3; the disease is retinal disorder.