DDIT3 and age-related macular degeneration: Western blot analyses showed that the AMD cybrids had significantly higher protein levels of Cleaved Caspase-3 (120.4%, Figure 3b), LC3B (49.1%, Figure 3d), and DDIT3 (261%, Figure 3f); and 38% reduced SOD2 protein levels in AMD cybrids (Figure 3h) (P<0.05) (Supplementary Table S6).