Recently, it has been reported that IL-22 pathway is indispensable for alleviating metabolic disorders and lack of IL-22 signaling contributed to the development of metabolic syndrome.18, 19, 20 Consistent with these results, our data demonstrated that IL-22 gene therapy not only strikingly alleviated hyperglycemia, but also markedly reduced serum levels of triglyceride and total cholesterol in STZ-induced diabetic mice, further unveiling the biological function of IL-22 in metabolism regulation. Here, IL22 is linked to Hyperglycemia.