IL22 and kidney disorder: Although the renoprotective effects of IL-22 in acute kidney injury have been investigated in recent years,21, 22 studies on the anti-fibrotic effects of IL-22 in renal diseases are still lacking.36, 37, 38, 39 Notably, to our knowledge, the findings from this study revealed for the first time that IL-22 could exert anti-fibrotic effects in kidney disease.