PLIN1 and cancer: Among the genes involved in intestinal phenotype, AMPK regulates hairy and enhancer of split 1 (HES1), trefoil factor 3 (TFF3), and the lipid-droplet associated protein ADFP. As much as 22 transcription factors were commonly significantly enriched in both fatty acids and cancer biomarkers datasets, such as metabolic responsive peroxisome proliferator-activating factors (PPARs) or well-known cancer-related factors such as V-Myc Avian Myelocytomatosis Viral Oncogene Homolog (MYC), which regulates HES1, P53, which regulates mucin 2 (MUC2), or Smads.