IL6 and cancer: Except Interleukin 6 and 8, and retinol binding protein (RBP) pathways (over-represented in Caco-2 cells differentiated versus undifferentiated) and potassium (over-represented in Caco-2 cells versus enterocytes) all of these signaling pathways were also significantly over-represented in the cancer biomarker dataset (Figure 1).