NOD2 and inflammatory bowel disease: For example, the interaction between miR-192 and the nucleotide-binding oligomerization domain-containing protein 2 (NOD2) gene may be relevant in the pathogenesis of IBD; SNP rs3135500 in the 3′-untranslated region (UTR) of NOD2 reduces the ability of miR-192 to inhibit NOD2 expression [18].