Contrary to this finding, the same variant of this MMP-9 polymorphism has been associated with a higher risk of gestational hypertension and preeclampsia in Kurdish and Chinese population [51,52]; also, some results suggest that this polymorphism may affect the therapeutic response to antihypertensive agents, concluding that this MMP-9 variant could help to identify those patients with a refractory response [37]. The gene discussed is MMP9; the disease is preeclampsia.