In addition, the coexistence of overlapping pathologies does not always match with the clinical manifestations due to the various cerebral distribution of abnormal protein deposits.14 This complex framework occurs in the context of multiple neurotransmitter deficiencies (including dopamine, noradrenaline, serotonin, and acetylcholine) and presence of genes that increase the dementia risk (such as ɑ-synuclein mutation (SNCA), the apolipoprotein ε4 (APOE4) allele, and the microtubule-associated protein tau (MAPT) H1 haplotype7). This evidence concerns the gene MAPT and dementia.