GSH augmentation deserves investigation as a beneficial therapeutic approach for not only PD but also numerous other CNS disorders for which GSH deficiency and GSH-related enzyme deficits have been documented (multiple sclerosis,25,26 autism,27–29 Alzheimer’s disease,30,31 schizophrenia,32,33 and bipolar disease34). Here, GSS is linked to early-onset autosomal dominant Alzheimer disease.