On the one hand, muscarinic antagonists, administered in low doses to avoid adverse atropinic side effects, are clinically useful drugs for the treatment of motor symptoms.47 On the other hand, increasing cholinergic tone by administering AChE inhibitors is an efficacious strategy for improving PDD,121 reducing fall rate,60 and probably also psychosis and RBD; however, well-conducted clinical trials in support of the latter claims are lacking. The gene discussed is ACHE; the disease is psychotic disorder.