In a subsequent trial, gait parameters were correlated with cholinergic and dopaminergic denervation in 125 nondemented PD patients and 32 controls.56 Cortical cholinergic denervation was heterogeneous, with 38 subjects with PD (30.4%) exhibiting cortical AChE activity below normal range and 21 subjects (16.8%) with PPN-thalamic AChE activity below normal range. Here, ACHE is linked to Parkinson disease.