Established mouse models of PD include the use of toxic chemicals, overexpression of wild type or mutated α-synuclein, or exogenously added α-synuclein formulas.17,18 The different models all have their strengths and limitations and one has to carefully correlate the phenotypic presentations (i.e., neuronal death, Lewy bodies,18,28 motor symptoms) of the model with the research questions to be asked. Here, SNCA is linked to Parkinson disease.