α-Synuclein is a major component of the amyloid aggregates found in Lewy-body inclusions, which are pathological hallmarks of PD, and mutations in α-synuclein are related to familial PD cases.1,2 The exact function of α-synuclein is unknown, but it is suggested to be involved in synaptic vesicle release and trafficking, physiological regulation of enzymes and transporters, and participating in neuronal survival by controlling the neuronal apoptotic response3 and appears to be present in soluble and membrane-associated forms at presynaptic nerve terminals.4–6. This evidence concerns the gene SNCA and Parkinson disease.