LRRK2 and Parkinson disease: Increasing lifespan through mutations in daf-2 has been shown to increase resistance to a variety of stresses including heat stress,30 oxidative stress,31 and osmotic stress.32 As both PD mutants exhibited increased sensitivity to different types of stress, we next determined the extent to which increasing lifespan through the daf-2 mutation could rescue the deficits in stress resistance in α-syn and LRRK2 transgenic worms.