There exists limited evidence about the role of specific RAS family members in HCC EMT, although the evidence suggests that K-RAS and H-RAS activation have a role in HCC EMT and metastasis.39,40 Not much is known about the different roles of NOTCH family members in cancer, although there is speculation that they have different roles in brain tumor development.41 There exists evidence that each of the NOTCH family members contributes to hepatocarcinogenesis. This evidence concerns the gene HRAS and hepatocellular carcinoma.