To determine the impact of miRNAs on cancer pathways, we perturbed the basal-like breast cancer cell line MDA-MB-231 (KRAS G13D, BRAF G464V, TP53 R280K and CDKN2A frameshift mutations) with 879 exogenous miRNA mimics and changes in protein levels were measured by RPPA. This evidence concerns the gene TP53 and cancer.