BC, breast cancer; BMI, body mass index; CTC, circulating tumour cells; ECM, extra-cellular matrix; FIA, fibro-adenoma; FS, “Flammer Syndrome”; GPs, general practitioners (family doctors); HER-2, human epidermal growth factor receptor 2; HIF-1, hypoxia-inducible factor 1; ТxNxМx, tumour size/number of affected lymph nodes/number of metastases; VEGF, vascular endothelial growth factor. The gene discussed is ERBB2; the disease is breast carcinoma.