In contrast to the lowest prevalence in Luminal A (2%), the highest prevalence (12%) of the local recurrence and the highest rates of distant metastases (27.4%) have been reported for the triple-negative BC followed by HER-2-positive (19.2%), Luminal B (12.1%) and Luminal A (6.4%) subtypes [8]. This evidence concerns the gene ERBB2 and breast cancer.