The results of the Aphinity trial with adjuvant pertuzumab are awaited and, therefore, both the regimens ACTH (anthracycline/cyclophosphamide/taxane/trastuzumab) and TCH (docetaxel/cyclophosphamide/trastuzumab) remain the standard of care in stage II/III HER2-positive breast cancer. This evidence concerns the gene ERBB2 and breast carcinoma.