Since previous studies have demonstrated that several inflammatory cytokines were dysregulated in IBD patients, and serum levels of IFN-γ, IL-17, and TNF-α are significantly up-regulated, while IL-10 is decreased in JKAP-knockout mice, we next asked whether there was a correlation between JKAP mRNA expression and the levels of IFN-γ, IL-17, TNF-α, and IL-10 in intestinal mucosa from IBD patients. The gene discussed is TNF; the disease is inflammatory bowel disease.