DUSP22 and Autoimmunity: And JKAP-knockout mice develop exacerbated inflammation and autoimmunity compared with wide-type mice and are more likely to present with experimental autoimmune encephalomyelitis (EAE), resulting from the enhanced T-cell-mediated adaptive immune responses with higher secretion of pro-inflammation cytokines including IFN-γ, IL-17, and IL-4 (12).