However, monocytes use FcγRIIc and FcγRI to a greater extent than cDCs and pDCs (51) and while examining the opsonization of HIV-1 virions by Env-specific IgG3 antibodies and their phagocytosis by monocytes may elucidate mechanisms by which vaccine-induced IgG antibodies prevent the acquisition of HIV-1 infection (128), this may not be so for control of chronic HIV-1 infection. This evidence concerns the gene IGHG3 and HIV-1 infection.