Similar to cyclosporine A, (-)mycousnine enamine selectively inhibited T cell proliferation, suppressed the expression of surface molecules (CD25 and CD69) and cytokines (IL-2 and IFN-γ) in activated T cells, and it did not show any effect on the proliferation of B cell and cancer cells (PANC-1 and A549) or the activation of macrophage. This evidence concerns the gene IFNG and cancer.