Fekih et al. (45) quantified circulating OPG levels in a childhood T1DM cohort (n = 143; mean age 12 years) with cardiometabolic risk factors such as prolonged duration (≥4 years) of diabetes, HbA1c ≥ 7%, dyslipidemia, and microalbuminuria (≥30 mg/24 h). This evidence concerns the gene TNFRSF11B and diabetes mellitus.