A sub-analysis of the TS group with aortic dilatation demonstrated a strong positive correlation between NT pro-BNP levels and the diameter of the ascending aorta as well as BSA-indexed ascending aortic dilatation confirming that there is indeed a relationship between NT pro-BNP levels and radiologically detectable aortic disease in TS women. Here, NPPB is linked to Ascending tubular aorta aneurysm.