This study demonstrated that NT pro-BNP levels were elevated in TS subjects as compared to healthy controls and that the NT pro-BNP levels were high irrespective of the presence of underlying aortic disease, confirming the findings from Gravholt et al. (11), but further elucidating that high NT pro-BNP levels are intrinsic to TS in the absence of underlying aortic disease and clinically detectable hypertension. The gene discussed is NPPB; the disease is Hypertension.