In addition, a more recent randomized, double blind, placebo-controlled trial involving adults with MetS (n = 57) aged 20–60 years showed supplementation of mixed T3 (400 mg/day) for 16 weeks exerted beneficial effects in chronic inflammation [reduced interleukin-6 (IL-6) and TNF-α] and lipid profiles (reduced TC, LDL-C, and HDL-C) in adults with MetS as compared to baseline (Heng et al., 2015). The gene discussed is IL6; the disease is metabolic syndrome.