Obesity and dyslipidemia induce abnormal growth of adipose tissue, contributing to the overproduction of inflammatory mediators [particularly TNF-α, IL-6, and interleukin-1 beta (IL-1β)] and activation of nuclear factor-kappa B (NF-κB) (Weng-Yew and Brown, 2011). This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.