SOD1 and amyotrophic lateral sclerosis: Although multiple mechanisms are proposed to drive ALS (Taylor et al., 2016), several recent unbiased studies in mutant SOD1 transgenic mice and induced pluripotent stem cell (iPSC)-derived patient motoneurons have identified endoplasmic reticulum (ER) stress as an early and transversal pathogenic mechanism underlying selective vulnerability of motoneurons in ALS (Saxena et al., 2009; Kiskinis et al., 2014; Filézac de L’Etang et al., 2015; Sun et al., 2015).