Some of the TFs that were downregulated in NLPs, including Esx1 (Asanoma et al., 2015), Bhlhe41 (Cui et al., 2016), and Dmrt1 (Krentz et al., 2009; Zou et al., 2016), have been reported to play critical roles in negatively regulating cancer cell and stem cell growth in other tissues. Here, BHLHE41 is linked to cancer.