We showed the following: (1) Nearly half of the CAN patients preserved similar levels of cytokine expression by NK cells as those in the CA group, although the average level was lower than in the CA group; (2) patients with higher baseline levels of HBcAb, HBsAg, and ALB, and lower levels of fibrosis had depressed NK-cell-driven IFN-γ and TNF-α levels; and (3) a statistically predictive nomogram was created based on the Cox regression model tailored to individual patients to identify antiviral cytokines produced by NK cells in CHB. The gene discussed is TNF; the disease is Crouzon syndrome-acanthosis nigricans syndrome.