IFNG and Crouzon syndrome-acanthosis nigricans syndrome: Direct correlations between NK cells and their subsets exhibiting IFN-γ with fibrosis value were detected in the CAN group but not in the CA group (r2 = 0.0500, p = 0.0294; r2 = 0.0913, p = 0.0072; and r2 = 0.1193; p = 0.0021; for groups of total NK, NKdim, and NKbright cells, respectively) (Fig. 4C, Supplementary Figures 5, 6).