MYOD1 and obesity due to melanocortin 4 receptor deficiency: In the present study, an investigation of their effects on C2C12 cells indicated they regulate MYOD, MYOG and RAGE genes, which agrees well with the findings of in vivo study, in which curcumin or gingerol administration increased muscle regeneration and reduced muscle atrophy and increases glucose metabolism to counteract the effect of high fat diet induced obesity in mouse models24, 40, 43–45.