Recently, obesity associated non-coding sequences in the FTO gene were found to be functionally connected to the nearby gene, IRX3, by directly interacting with the promoters of this gene33, suggesting obesity SNPs located inside the FTO gene may regulate gene expression other than FTO. Our GWAS lead SNP rs9936385 in the FTO locus was in LD with the obesity GWAS SNP and located in the same haplotype. This evidence concerns the gene IRX3 and obesity due to melanocortin 4 receptor deficiency.