For rs9936385, we also examined IRX3 and IRX5 expression in skeletal muscle tissues, as recent reports have implicated GWAS SNPs associated with obesity in intron 2 of the FTO gene as being associated with IRX3 and IRX5 gene expression in brain33 and adipose tissue34. The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.