Interestingly, in contrast to round TDP-43 inclusions, skein-like amorphous TDP-43 inclusions did not contain Hsp40 in the subset of ALS cases analyzed (Fig. 9c, see white arrowhead), suggesting that Hsp40 recruitment to TDP-43 aggregates may alter inclusion morphology and/or processing of its contents for degradation. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.