TARDBP and amyotrophic lateral sclerosis: The cytoplasmic acetylation-mimic TDP-43-ΔNLS-K145Q produced inclusions that were more robustly phospho-TDP-43 immunoreactive (Fig. 1c, see TDP-43-ΔNLS-K145Q), resembling full-length cytoplasmic TDP-43 pathology in ALS spinal cord.