This includes RUNX1 (data not shown), known to be involved in B cell and lymphoid development, and whose deregulation can accelerate Myc-induced lymphomagenesis42, or the lysine (K)-specific demethylase 2B (KDM2B), an important mediator of hematopoietic cell development that has opposing roles in tumor progression depending on the cellular contest43. Here, MYC is linked to neoplasm.