LMP1 is known to modulate the levels of DNMTs in GC B cells39, indeed our data indicate that during EBV infection LMP1 increases the recruitment of the DNMTs to the promoter of ID3; this activity of LMP1, that appears to require its ability to induce NFκB, could then result in increased methylation of ID3 promoter and silencing of its gene expression; further studies are needed to validate this hypothesis. The gene discussed is NFKB1; the disease is Epstein-Barr virus infection.