APOC3 and familial chylomicronemia syndrome: Although it has only been studied in familial chylomicronemia syndrome (defective catalysis in LPL leading to elevated ApoC-III and TG levels), oligonucleotide antisense technology has yielded an inhibitor to ApoC-III messenger RNA, ISIS 304801, which has reduced ApoC-III serum levels by at least 71% among three patients20.