It is known that ischemia causes a rapid loss of high-energy phosphate compounds, generalized depolarization, and increased neuronal cytosolic Ca2+, which leads to the dysfunction of cytosolic proteins and signal chemicals, including μ-calpain, calcineurin, NOS, and free arachidonic acid that will further exacerbating the situation27–30. The gene discussed is CAPN2; the disease is ischemia.