The efficacy of EpCAM aptamer-survivin siRNA chimera in the downregulation of survivin was initially tested on EpCAM-positive colorectal cancer cell line HT-29 with the EpCAM-negative cell line HEK-293T and a survivin RNAi-deficient variant chimera as negative controls (Supp. The gene discussed is BIRC5; the disease is colorectal cancer.