The downregulation of survivin in empowering traditional chemotherapeutic agents to eliminate colorectal cancer stem cell is not limited to 5-FU as the combined treatment with aptamer-survivin siRNA chimera and oxaliplatin had a similar efficacy in the impairment of self-reviewal capacity of HT-29 colorectal cancer stem cells (Supp. The gene discussed is BIRC5; the disease is colorectal cancer.