Although these cytokines are shared in the pathogenesis of metabolic dysfunction and RA [1, 5], only trends towards reduction of TNFα, IL6, and IL1β transcripts were observed in the arthritic paws from the Wnt5a cKO mice (Additional file 1: Figure S6) as was a trend toward diminished lymphocyte infiltration in the histological sections (Additional file 1: Figure S5). Here, TNF is linked to rheumatoid arthritis.