To validate higher CASC15 expression in t(8;21) and t(12;21) rearranged leukemia, we analyzed two datasets deposited in NCBI’s Gene Expression Omnibus database (GEO) (N = 102 ALL, N = 85 AML; GSE17459 and GSE75461) [25, 26]. This evidence concerns the gene CASC15 and acute lymphoblastic leukemia.