Among the genes involved in patient 7 (PRKAB2, PDIA3P, FMO5, CHD1L, BCL9, ACP6, GJA5, GJA8, GPR89B, PDZK1P1, NBPF11, NBPF24), with current knowledge, none seems to be related with congenital hypothyroidism. This evidence concerns the gene FMO5 and congenital hypothyroidism.