Moreover, the expression of several WBP2NL-related genes such as WW domain-containing E3 ubiquitin protein ligase 1 (WWP1), neural precursor cell expressed developmentally downregulated 4 (NEDD4), BCL2-associated athanogene 3 (BAG3), and WWOX is tested in both malignant breast and normal breast cancer tissues, and all are involved in the tumorigenic signal networks. This evidence concerns the gene BAG3 and breast cancer.