In addition, clinicopathological analysis revealed that the overexpression of both genes was closely correlated with Grades III and IV (HOXD-AS1, p = 0.0381; ARHGAP11A, p = 0.0006) and with PVTT tumor invasion (HOXD-AS1, p = 0.0419; ARHGAP11A, p = 0.0079) (Additional file 1: Table S3). The gene discussed is HAGLR; the disease is neoplasm.