TCF4 and leukemia: Many genes known as unfavorable biomarkers were up-regulated, including leukemia-associated molecules, such as: (1) genes (Wnt2B and Wnt9A) of Wnt signaling pathway involved in leukemogenesis; (2) independent adverse prognostic factors in AML including WT1, miR-155HG [3, 4], SOCS2 [15], TCF4 [16], MAP7 [17], ID1 [18] and MSI2 [19].