Some of the more commonly observed alarm signals, which may point to the presence of insulin manipulation, include: persistently high glycosylated hemoglobin levels, frequent referral to the emergency department for diabetic ketoacidosis, tendency towards thinness, dissatisfaction with personal body image, hyperglycemia with frequent candidiasis or urinary infections, and poor compliance with check-up visits and treatments for diabetes [17]. This evidence concerns the gene INS and diabetes mellitus.