The TLR4 activation-induced or CXCR3-mediated CXCL10 upregulation can exert important roles in arthritis progression through TLR4 and CXCR3, suggesting that it could form a positive feedback loop between CXCL10 and its receptors TLR4 and/or CXCR3. This evidence concerns the gene TLR4 and arthritic joint disease.