MDSCs express PD-L1 at lower level than tumor cells [85], and accordingly, we assume that \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$\varepsilon _{M}M=\frac {1}{4}\varepsilon _{C}C$\end{document}εMM=14εCC, so that εM=εCC/4M=εC/2=0.005. This evidence concerns the gene CD274 and neoplasm.