It was observed that in univariate analyses, the duration of HIV infection with odd ratio (OR) (1.101) and 95% confidence interval (CI) (1.011–1.080) (P<0.05), nadir CD4+ count with OR (1.989) and CI (1.374–2.100) (P<0.05), E2 with OR (-0.154) and CI (-0.138, -0.162) (P<0.05) were significantly associated with thyroid and reproductive dysfunction. The gene discussed is CD4; the disease is HIV infectious disease.