Similarly, NRG1 was more highly expressed in HNSCC tumors bearing wild-type PI3K, with a prevalence of ~85% of HNSCC [31] compared to PI3K-mutated tumors (defined by known activating mutations in exons 9 and 20) (p-value of 0.0013) (S1 Fig). The gene discussed is NRG1; the disease is head and neck squamous cell carcinoma.