Analysis of a large panel of HNSCC patient samples demonstrated that NRG1 expression was significantly associated with the EGFR ligands TGFα and AREG, but not the remaining five EGFR ligands (EGF, betacellulin, HB-EGF, epiregulin, and epigen). The gene discussed is AREG; the disease is head and neck squamous cell carcinoma.