NRG1 and neoplasm: KTN3379 exhibited significant anti-tumor only in models that expressed both NRG1 and high H11D levels (Cal27 and CTG-0434), but did not have significant activity in a NRG1 positive model with low H11D (CTG-0776) or vice versa, in a NRG1-negative model bearing high H11D levels (CTG-0840).