Quantitative H11D analysis of HNSCC cell lines revealed a correlation between H11D levels and KTN3379 activity as measured by its anti-proliferative activity in combination with cetuximab (R2 = 0.48) or by phospho-AKT inhibition (R2 = 0.76) (Fig 6E and 6F). This evidence concerns the gene AKT1 and head and neck squamous cell carcinoma.