Experimental animal models of epilepsy have showed PE mechanisms that can promote the improvement of several aspects related to epilepsy, such as delayed kindling model development, improvement of spatial memory, increased brain-derived neurotrophic factor and hilo fibers of dentate gyrus in the hippocampus, and decreased frequency and intensity of seizures and spikes in the EEG during PA and after a PE training program [33–37]. This evidence concerns the gene BDNF and epilepsy.