The effect of TDB on the two macrophage phenotypes is substantial, with TDB enhancing the M1‐like phenotype of GM‐CSF macrophages and down‐regulating M2‐like markers commonly associated with TAMs and cancer progression 31, 47, 48 for both GM‐CSF and M‐CSF/IL‐4 BMMs. The gene discussed is CSF1; the disease is cancer.