NFE2L2 and Hypoglycemia: Sodium selenite, homocysteine (Hcy), valproic acid (VPA), lack/excessive O2, hypoglycemia under hypoxia, methylglyoxal (MGO) are reported as Nrf2 suppressors (Fig. 1), which aggravate cataract formation by inhibiting the Nrf2‐dependent antioxidant protection in lenses (Table 1).