Autosomal dominant mutations in RyR2, the gene encoding for the ryanodine receptor type 2 (CPVT1) or recessive mutations in CASQ2, the gene encoding for calsequestrin 2 (CPVT2) are the most common mutations linked to CPVT, resulting in spontaneous Ca2+ release from the SR and consequent DADs, triggered activity, and ventricular tachyarrhythmias [112]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.