The first report showing that hiPSCs could model a cardiac channelopathy was the study of Moretti et al. [26], where hiPSC-CMs from a LQT1 patient (carrying the KCNQ1-R190Q mutation) recapitulated the electrical phenotype of the disease; patch clamp analysis revealed AP prolongation and decreased IKs in LQT1 hiPSC-CMs as compared to control hiPSC-CMs. The gene discussed is KCNQ1; the disease is long QT syndrome 1.