RYR2 and catecholaminergic polymorphic ventricular tachycardia: The first study modeling CPVT using hiPSCs was performed by Itzaki et al., where CPVT1 hiPSC-CMs carrying the RYR2-M4109R mutation showed increased DADs incidence and Ca2+ transient irregularities as compared to control hiPSC-CMs, which were further exacerbated by β-adrenergic stimulation [113].