As shown in Table 6, Fig. 4A, and Fig. 4B, similar to weight-adjusted lean body mass, weight-adjusted CC negatively correlated with systolic and diastolic blood pressure; fasting plasma glucose, HbA1c, alanine aminotransferase, TG, and insulin levels; and insulin resistance indices, such as H-IR and HOMA-IR (Fig. 4A), and positively correlated with HDL-C levels and insulin sensitivity indices, such as Matsuda index (Fig. 4B) and QUICKI. The gene discussed is INS; the disease is Insulin resistance.